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[孕周小于33周的早产儿的发病率和死亡率]

[Morbidity and mortality of premature infants of less than 33 weeks].

作者信息

Papiernik E, Combier E

机构信息

Faculté de Médecine Cochin, Université René Descarte, Paris.

出版信息

Bull Acad Natl Med. 1996 May;180(5):1017-27; discussion 1027-31.

PMID:8963705
Abstract

The present study in a case-control study in a population based collection of data of all births from 22 to 32 weeks in all maternities of the Seine-Saint-Denis district for three years, 999 on 67819 total births. The study describes the site of births by level of perinatal care (level 3 maternity associated with a neonatal intensive care unit, level 2 with a neonatal pediatric ward without intensive care, and level 1 without any of these pediatric services. The proportion of births at a level 3 maternity is 6.3% for all births, and 12.9% for live birth of less than 33 weeks. The study describes the transfers of the live babies to a neonatal intensive care by external transfers from level 1 and level 2 units or internal transfers in level 2 and 3 units. All babies are transferred. The study describes the per partum and neonatal deaths up to 28 days by week of gestation duration and site of birth. The study uses the comparison between the deaths during delivery (from 28 to 32 weeks) and in the first 28 days compared to controls, using a regression analysis method. The risk of per partum and neonatal death is: OR = 8.08 [1.03-76.40] when site of birth 2 is compared to 3 and OR = 11.78 [1.33-103.77] when site of birth 1 is compared to 3. The study shows that the french obstetricians and pediatricians have not accepted the international consensus proposing that births of less than 33 weeks should take place in level 3 perinatal units, goal which is reached for 80% of those births, with less neonatal deaths and developmental handicaps.

摘要

本研究是一项病例对照研究,基于塞纳-圣但尼区所有产科三年来22至32周所有分娩的数据收集,在67819例总分娩中有999例。该研究按围产期护理水平描述了分娩地点(与新生儿重症监护病房相关的3级产科、设有无重症监护的新生儿儿科病房的2级产科以及没有任何这些儿科服务的1级产科)。3级产科的分娩比例在所有分娩中为6.3%,在孕周小于33周的活产中为12.9%。该研究描述了活产婴儿通过从1级和2级单位的外部转运或2级和3级单位的内部转运至新生儿重症监护病房的情况。所有婴儿都被转运。该研究按孕周和分娩地点描述了直至28天的产后和新生儿死亡情况。该研究使用回归分析方法,比较了分娩期间(28至32周)和出生后头28天与对照组的死亡情况。与3级相比,当分娩地点为2级时,产后和新生儿死亡风险为:OR = 8.08 [1.03 - 76.40];当分娩地点为1级时,与3级相比,OR = 11.78 [1.33 - 103.77]。该研究表明,法国产科医生和儿科医生尚未接受国际共识,即孕周小于33周的分娩应在3级围产期单位进行,80%的此类分娩实现了这一目标,新生儿死亡和发育障碍较少。

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