Forni A, Alessio L, Cortona G, Erba P, Feltrin G, Pesatori A
Istituto di Medicina del Lavoro, Università degli Studi di Milano, Clinica del Lavoro L. Devoto.
Med Lav. 1996 May-Jun;87(3):265-7.
The health surveillance of workers exposed to antineoplastic drugs is based on the fact that these substances are potentially carcinogenic to humans and can cause adverse reproductive effects, as well as irritative and allergic reactions. Health checks must be carried out before starting the job and at periodic intervals thereafter depending on the degree of exposure. These checks will have to evaluate possible physiological and pathological conditions of individual susceptibility. In addition to occupational and pathological history, and physical examination, health surveillance must include tests for the evaluation of hemopoietic, renal and liver functions. Cytogenetic studies on individual workers can be proposed only after documented abnormal exposures to antineoplastic drugs or in case of adverse effects suspected to be caused by this type of exposure.
这些物质对人类具有潜在致癌性，可导致不良生殖影响以及刺激和过敏反应。必须在开始工作前进行健康检查，并在此后根据接触程度定期进行检查。这些检查必须评估个体易感性的可能生理和病理状况。除职业和病史以及体格检查外，健康监测还必须包括评估造血、肾脏和肝脏功能的测试。只有在有记录的抗肿瘤药物异常接触或怀疑由这种接触引起不良反应的情况下，才可以对个体工人进行细胞遗传学研究。
