Macis G, Salcuni M, Cotroneo A R, Cina G, Marano P
Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma.
Radiol Med. 1996 Jul-Aug;92(1-2):63-71.
Thromboembolism is presently the third most frequent cardiovascular disease, with an incidence of deep venous thrombosis of 800,000 cases a year in the USA. The clinical diagnosis of the condition is difficult and noninvasive procedures are poorly reliable, which makes the diagnosis and treatment of deep venous thrombosis appropriate in the patient with clinically suspected pulmonary embolism. Color-Doppler US is now replacing phlebography in the diagnosis of deep venous thrombosis. Proximal deep venous thrombosis is always at high risk for embolism (50%). Isolated calf thrombi may spread into proximal veins and thus cause severe embolism. Therefore, the early detection of thrombus site and extent and a timely treatment before embolism are of the utmost importance. Color-Doppler US is a noninvasive technique which can show deep venous thrombosis with 95% sensitivity in the proximal and 55% sensitivity in the distal districts in asymptomatic patients. This examination must be used not only to confirm a diagnostic suspicion of deep venous thrombosis, but also to screen high-risk patient and to monitor distal thrombosis. In the secondary prophylaxis of pulmonary embolism, the radiologist must perform a mechanical interruption of inferior vena cava by positioning a caval filter. Caval filters can be temporary or definitive; standard indications for caval filter positioning are a contraindication to anticoagulant therapy and the onset of pulmonary embolism in spite of anticoagulant drugs. A further indication is the presence of floating thrombi in the femoroiliac-caval trunk. Multidisciplinary groups including the hematologist, the radiologist and the clinician should plan the diagnostic and therapeutic approach and participate in the decision-making process. In our department, from January, 1992, to June, 1995, sixty-five caval filters were positioned in 62 patients selected out of 260 candidates. Three complications only were observed; one patient had recurrent pulmonary embolism and three patient had caval thrombosis spreading beyond the filter. In 198 patients in whom no caval filter was implanted, pulmonary embolism did not recur. At present, the role of the radiologist is markedly changing, especially in the management of this condition. On the one hand, radiologists must diagnose thromboembolism as a whole and not only its pulmonary evidence; on the other hand, they play a major operational and interventional role in the treatment of thromboembolism patients.
血栓栓塞是目前第三常见的心血管疾病,在美国,深静脉血栓形成的发病率为每年80万例。该病的临床诊断困难,非侵入性检查的可靠性较差,这使得在临床上怀疑有肺栓塞的患者中,深静脉血栓形成的诊断和治疗变得尤为重要。彩色多普勒超声目前正在取代静脉造影用于深静脉血栓形成的诊断。近端深静脉血栓形成总是有很高的栓塞风险(50%)。孤立的小腿血栓可能蔓延至近端静脉,从而导致严重的栓塞。因此,早期发现血栓部位和范围并在栓塞前及时治疗至关重要。彩色多普勒超声是一种非侵入性技术,在无症状患者中,其对近端深静脉血栓形成的显示敏感性为95%,对远端区域的敏感性为55%。这项检查不仅必须用于证实对深静脉血栓形成的诊断怀疑,还必须用于筛查高危患者以及监测远端血栓形成。在肺栓塞的二级预防中,放射科医生必须通过放置腔静脉滤器对下腔静脉进行机械性阻断。腔静脉滤器可以是临时性的或永久性的;放置腔静脉滤器的标准指征是抗凝治疗的禁忌证以及尽管使用了抗凝药物仍发生肺栓塞。另一个指征是股髂-腔静脉主干中存在漂浮血栓。包括血液科医生、放射科医生和临床医生在内的多学科团队应规划诊断和治疗方法并参与决策过程。在我们科室,从1992年1月至1995年6月,在260名候选患者中选出的62例患者中放置了65个腔静脉滤器。仅观察到3例并发症;1例患者发生复发性肺栓塞,3例患者发生腔静脉血栓形成并蔓延至滤器之外。在198例未植入腔静脉滤器的患者中,肺栓塞未复发。目前,放射科医生的作用正在显著改变,尤其是在这种疾病的管理方面。一方面,放射科医生必须全面诊断血栓栓塞,而不仅仅是其肺部表现;另一方面,他们在血栓栓塞患者的治疗中发挥主要的操作和介入作用。