Bonnet J L
Service de cardiologie A, CHU Timone, Marseille.
Arch Mal Coeur Vaiss. 1995 Nov;88(11 Suppl):1781-4.
The prognosis of thromboembolic disease depends, to a large degree, on the deep venous thrombosis. It is located in the legs in nearly 80% of cases and proximal to the popliteal vein in one out of two patients. It is the cause of recurrence and at longer term, of post-thrombotic disease, the frequency of which contrasts with the rarity of chronic post-embolic cor pulmonale. The deep vein thrombosis is often neglected, either because it has no clinical expression or because the symptoms it causes regress rapidly with treatment. Venous ultrasonography by a skilled operator, a painless and easily repeated investigation, is the method of first intention. When the thrombus is not well visualised, it is necessary to complete the investigation with bilateral phlebocavography in free flow or with a computerised tomography scan if the vena cava is poorly seen. The treatment of the pulmonary embolism depends on its size, its tolerance, the embolic source and sites of embolism. Severe pulmonary embolism may require surgical embolectomy at the outset, during which inferior vena cava interruption should be systematic. When thrombolytic therapy is considered, the implantation of a temporary caval filter should be proposed, especially if the thrombus is "floating" or extends into the inferior vena cava. If pulmonary embolism is associated with a recent proximal venous thrombosis it would seem logical to propose surgical thrombectomy or thrombolysis, at least in young patients. Conversely, distal deep vein thrombosis only requires heparin therapy. Interruption of the inferior vena cava is essential when embolism complicates well-treated deep vein thrombosis or when the thrombosis becomes more extensive despite effective treatment. It is also advisable when pulmonary sequellae are severe, long-term anticoagulant therapy is contra-indicated or when the aetiology of the thromboembolism cannot be determined.
血栓栓塞性疾病的预后在很大程度上取决于深静脉血栓形成。近80%的病例位于腿部,每两名患者中就有一名血栓位于腘静脉近端。它是复发的原因,从长远来看,也是血栓形成后疾病的原因,其发生率与慢性肺栓塞后综合征的罕见形成对比。深静脉血栓形成常常被忽视,要么是因为它没有临床表现,要么是因为其引起的症状经治疗后迅速消退。由技术熟练的操作人员进行静脉超声检查,这是一种无痛且易于重复的检查方法,是首选的检查方法。当血栓显示不清时,有必要通过自由流动的双侧静脉腔造影术来完善检查,或者如果下腔静脉显示不清,则进行计算机断层扫描。肺栓塞的治疗取决于其大小、耐受性、栓子来源和栓塞部位。严重的肺栓塞可能一开始就需要进行手术取栓,在此期间应常规进行下腔静脉阻断。当考虑进行溶栓治疗时,应建议植入临时腔静脉滤器,特别是如果血栓是“漂浮的”或延伸至下腔静脉。如果肺栓塞与近期的近端静脉血栓形成相关,至少对于年轻患者,建议进行手术取栓或溶栓似乎是合理的。相反,远端深静脉血栓形成仅需要肝素治疗。当栓塞使已得到良好治疗的深静脉血栓形成复杂化,或者尽管进行了有效治疗血栓仍变得更广泛时,下腔静脉阻断是必要的。当肺部后遗症严重、长期抗凝治疗禁忌或血栓栓塞的病因无法确定时,这样做也是可取的。