[病毒特异性蛋白在实验性马尔堡热免疫发生中的有效性]
[Effectiveness of virus-specific proteins in immunogenesis during experimental Marburg fever].
作者信息
Donchenko V V, Lebedev V N, Markin V A, Firsova I V
出版信息
Vopr Virusol. 1996 Sep-Oct;41(5):216-8.
PMID:8967067
Abstract
The protective properties of early virus-specific proteins (EVSP) of Marburg virus have been studied. Immunoglobulins to EVSP in combination with immunoglobulins to UV-inactivated Marburg virus prevented lethal infection in Marburg virus infected guinea pigs. More than 80% of guinea pigs immunized by mixture of EVSP and UV-inactivated Marburg virus survived after challenge with 25 LD50 of Marburg virus. The explanation of this phenomenon and its further utilization are discussed.
摘要
对马尔堡病毒早期病毒特异性蛋白（EVSP）的保护特性进行了研究。针对EVSP的免疫球蛋白与针对紫外线灭活的马尔堡病毒的免疫球蛋白联合使用，可预防马尔堡病毒感染的豚鼠发生致命感染。用EVSP和紫外线灭活的马尔堡病毒混合物免疫的豚鼠，在接受25个半数致死剂量（LD50）的马尔堡病毒攻击后，超过80%存活。文中讨论了这一现象的解释及其进一步应用。
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