[慢性阻塞性支气管炎成年患者呼吸道合胞病毒抗原持续存在期间抗呼吸道合胞体液免疫的特征]
[Characteristics of anti-respiratory syncytial humoral immunity during persistence of respiratory syncytial virus antigens in adult patients with chronic obstructive bronchitis].
作者信息
Krivitskaia V Z, Iakovleva N V, Aleksandrova N I
出版信息
Vopr Virusol. 1996 Sep-Oct;41(5):234-7.
Specific humoral immune response has been studied in 8 patients with chronic obstructive bronchitis, in whom the persistence of RSV was detected, and in a group of patients without RSV persistence. Humoral immunity in patients with RSV persistence vs. those with acute and chronic bronchitis without viral persistence was characterized by the following features: a) earlier and more active production of IgG and, even more so, IgM and IgA; b) long persistence of high titers of anti-RSV IgG, IgM, and IgA-up to 17, 28, and 30 weeks, respectively; c) low anti-RSV neutralizing activity of serum antibodies.
对8例检测到呼吸道合胞病毒（RSV）持续存在的慢性阻塞性支气管炎患者以及一组未检测到RSV持续存在的患者的特异性体液免疫反应进行了研究。与急性和慢性支气管炎但无病毒持续存在的患者相比，RSV持续存在患者的体液免疫具有以下特征：a）IgG产生更早且更活跃，IgM和IgA更是如此；b）抗RSV IgG、IgM和IgA高滴度长期持续存在，分别长达17周、28周和30周；c）血清抗体的抗RSV中和活性较低。
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