Krivitskaia V Z, Iakovleva N V
Vopr Virusol. 1992 May-Jun;37(3):146-9.
The levels of specific IgG and IgM were determined in 72 patients with verified respiratory syncytial (RS) virus infection: 11 patients with acute delayed bronchitis (ADB), 26 with recurring bronchitis (RB) 35 with chronic obstructive bronchitis (ChOB), by indirect enzyme immunoassay; RS virus was detected by direct immunofluorescent technique. The activity of the inflammatory process in the bronchi was shown to depend upon RS infection activity in cases of ChOB and RB. RS infection was observed to be significantly dependent on obstruction and bronchospasms. The specific humoral response was reduced and delayed in ChOB and RB as compared to acute bronchitis. The possibility of long-term persistence of RS virus antigen in chronic and recurring forms of bronchitis was demonstrated.
采用间接酶免疫测定法测定了72例经证实的呼吸道合胞（RS）病毒感染患者的特异性IgG和IgM水平，其中11例为急性迁延性支气管炎（ADB）患者，26例为复发性支气管炎（RB）患者，35例为慢性阻塞性支气管炎（ChOB）患者；采用直接免疫荧光技术检测RS病毒。结果显示，在ChOB和RB病例中，支气管炎症过程的活动取决于RS感染的活动。观察到RS感染明显依赖于阻塞和支气管痉挛。与急性支气管炎相比，ChOB和RB患者的特异性体液反应降低且延迟。证实了RS病毒抗原在慢性和复发性支气管炎中长期持续存在的可能性。
