Fagard R, Macor F, Vanhaecke J
Department of Molecular and Cardiovascular Research, University of Leuven, Belgium.
Acta Cardiol. 1995;50(5):369-80.
Short-term heart rate and blood pressure variability were assessed in 62 patients, studied within 1 month, at 1, at 2 or at 3-5 years after cardiac transplantation and in 13 healthy control subjects. Means and total variances were calculated and the powers of the low frequency (LF, 0.07-0.14 EqHz) and of the high frequency (HF, 0.14-0.35 EqHz) components were derived from power spectral analysis. Mean heart period, its total variance and the powers of the LF and HF components were lower in the transplanted patients than in the controls (P < 0.001). The total variance and the LF and HF powers differed significantly among the groups of transplanted patients (P < 0.01) and intergroup comparison showed significantly higher values in patients 3-5 years after transplantation than in those studied within 1 month. The variance of systolic blood pressure and its power spectrum did not differ between patients and controls. The results suggest that partial functional reinnervation of the sinus node occurs after heart transplantation in man.
对62例心脏移植患者和13名健康对照者进行了短期心率和血压变异性评估。这些患者在心脏移植后1个月、1年、2年或3 - 5年接受研究，时间均在1个月内。计算了均值和总方差，并通过功率谱分析得出低频（LF，0.07 - 0.14 EqHz）和高频（HF，0.14 - 0.35 EqHz）成分的功率。移植患者的平均心动周期、其总方差以及LF和HF成分的功率均低于对照组（P < 0.001）。移植患者组之间的总方差以及LF和HF功率存在显著差异（P < 0.01），组间比较显示，移植后3 - 5年的患者的值显著高于移植后1个月内接受研究的患者。患者与对照组之间的收缩压方差及其功率谱无差异。结果表明，人类心脏移植后窦房结会发生部分功能性再支配。
