Klochkov S A, Alekseevskikh Iu G, Seniakovich V M
Arkh Patol. 1996 May-Jun;58(3):54-8.
The lungs and heart of 16 children with extrahepatic block of portal circulation who had died of esophageal-gastric bleeding and postoperative complications were studied histologically. The signs of restructuring of the lung microcirculation bed showing development of secondary pulmonary hypertension were observed in all the patients regardless of the duration and degree of portal hypertension. This was manifested in hypertrophy of the artery walls of the 2nd and 3rd order, hyperelastosis and sclerosis of their intima. "Arterialization" of the wall of the lobular and interlobular veins, arterio-venous, veno-venular and glomus anastomoses, focal alveolar proteinosis, hyperplasia and metaplasia of bronchial epithelium were observed. Irregular hypertrophy and degeneration of cardiomyocytes up to necrosis of some units were found in the heart. Pericellular and perivascular sclerosis developed in the subendocardial areas.
对16例死于食管胃出血及术后并发症的肝外门静脉循环受阻儿童的肺和心脏进行了组织学研究。所有患者均观察到肺微循环床重构的迹象，表明继发性肺动脉高压的发展，且与门静脉高压的持续时间和程度无关。这表现为二级和三级动脉壁肥厚、内膜弹力纤维增生和硬化。观察到小叶和小叶间静脉壁的“动脉化”、动静脉、静脉静脉和球旁吻合、局灶性肺泡蛋白沉积症、支气管上皮增生和化生。心脏中发现心肌细胞不规则肥大和变性，直至部分心肌细胞坏死。心内膜下区域出现细胞周和血管周硬化。
