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Prevention of restenosis after coronary angioplasty with low-density lipoprotein apheresis.

作者信息

Adachi H, Niwa A, Shinoda T

机构信息

Department of Medicine, Musashino Red Cross Hospital, Tokyo, Japan.

出版信息

Artif Organs. 1995 Dec;19(12):1243-7. doi: 10.1111/j.1525-1594.1995.tb02293.x.

DOI:10.1111/j.1525-1594.1995.tb02293.x
PMID:8967882
Abstract

A prospective study was performed to determine whether low-density lipoprotein (LDL) apheresis, when performed only immediately before and after percutaneous transluminal coronary angioplasty (PTCA), is effective in preventing restenosis of coronary artery lesions following PTCA. Thirty-six patients with coronary heart disease (CHD) and hypercholesterolemia were divided into 2 groups. The 9 patients in the LDL group underwent LDL-apheresis 1 day before and 5 days after PTCA while the 27 patients of the control group underwent PTCA but did not undergo LDL-apheresis. Follow-up coronary angiography (CAG) was performed 4 months after PTCA. The rate of restenosis of coronary artery lesions was significantly lower in the LDL group (0%) than in the control group (30%). These findings suggest that LDL-apheresis, when performed before and after PTCA, is effective in preventing restenosis of coronary artery lesions in patients with CHD and hypercholesterolemia.

摘要

相似文献

1
Prevention of restenosis after coronary angioplasty with low-density lipoprotein apheresis.
Artif Organs. 1995 Dec;19(12):1243-7. doi: 10.1111/j.1525-1594.1995.tb02293.x.
2
Short-term and long-term effects of low-density lipoprotein (LDL) apheresis on restenosis after percutaneous transluminal coronary angioplasty (PTCA): is lowering Lp(a) by LDL apheresis effective on restenosis after PTCA?
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3
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4
Effects of LDL apheresis on restenosis after angioplasty.低密度脂蛋白去除术对血管成形术后再狭窄的影响。
Chem Phys Lipids. 1994 Jan;67-68:339-43. doi: 10.1016/0009-3084(94)90155-4.
5
Effectiveness of LDL-apheresis in preventing restenosis after percutaneous transluminal coronary angioplasty (PTCA): LDL-apheresis angioplasty restenosis trial (L-ART).低密度脂蛋白去除术预防经皮腔内冠状动脉成形术（PTCA）后再狭窄的有效性：低密度脂蛋白去除术血管成形术再狭窄试验（L-ART）
Chem Phys Lipids. 1994 Jan;67-68:399-403. doi: 10.1016/0009-3084(94)90162-7.
6
Long-term efficacy of low-density lipoprotein apheresis on coronary heart disease in familial hypercholesterolemia. Hokuriku-FH-LDL-Apheresis Study Group.低密度脂蛋白分离术对家族性高胆固醇血症冠心病的长期疗效。北陆家族性高胆固醇血症-低密度脂蛋白分离术研究组。
Am J Cardiol. 1998 Dec 15;82(12):1489-95. doi: 10.1016/s0002-9149(98)00692-4.
7
Prevention of restenosis after percutaneous transluminal coronary angioplasty by reducing lipoprotein (a) levels with low-density lipoprotein apheresis. Low-Density Lipoprotein Apheresis Angioplasty Restenosis Trial (L-ART) Group.通过低密度脂蛋白单采降低脂蛋白(a)水平预防经皮腔内冠状动脉成形术后再狭窄。低密度脂蛋白单采血管成形术再狭窄试验（L-ART）组。
Am J Cardiol. 1994 Jun 1;73(15):1037-40. doi: 10.1016/0002-9149(94)90279-8.
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Association of an acute reduction in lipoprotein(a) with coronary artery restenosis after percutaneous transluminal coronary angioplasty.经皮腔内冠状动脉成形术后脂蛋白(a)急性降低与冠状动脉再狭窄的关联。
Circulation. 1997 Jul 1;96(1):166-73.
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Clinical application and effectiveness of low-density lipoprotein apheresis in the treatment of coronary artery disease.低密度脂蛋白分离术在冠状动脉疾病治疗中的临床应用及疗效
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State of percutaneous transluminal coronary artery angioplasty and effectiveness of low-density lipoprotein apheresis.经皮腔内冠状动脉成形术的现状及低密度脂蛋白分离术的有效性。
Ther Apher. 2001 Aug;5(4):226-31. doi: 10.1046/j.1526-0968.2001.00339.x.

引用本文的文献

1
High preprocedural non-HDL cholesterol is associated with enhanced oxidative stress and monocyte activation after coronary angioplasty: possible implications in restenosis.术前高非高密度脂蛋白胆固醇与冠状动脉成形术后氧化应激增强及单核细胞活化相关：对再狭窄可能的影响。
Heart. 2003 Jul;89(7):773-9. doi: 10.1136/heart.89.7.773.