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Preparation and in vitro antibacterial activity of 9-O-glycosyloxime derivatives of erythromycin A, a new class of macrolide antibiotics.

作者信息

Grandjean C, Lukacs G

机构信息

Institut de Chimie des Substances Naturelles du CNRS, Gif sur Yvette, France.

出版信息

J Antibiot (Tokyo). 1996 Oct;49(10):1036-43. doi: 10.7164/antibiotics.49.1036.

DOI:10.7164/antibiotics.49.1036
PMID:8968398
Abstract

9-O-Glycosyloxime derivatives of erythromycin A have been synthesized and their in vitro antibacterial activity compared with that of erythromycin A (1). This new class of macrolide antibiotics showed reduced antibacterial spectrum. However, some derivatives were as or more active than erythromycin A (1) against strains, responsible for respiratory track infections, such as Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.

摘要

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