临床神经免疫学

Clinical neuroimmunology.

作者信息

Xu X, Zhang H, Guo H, Wang X, Sun H, Han X, Li B, Pang F, Wang H, Wen S G, Jiang Y, Tan M

机构信息

Department of Neurology, Beijing Hospital, Beijing, P. R. China.

出版信息

Adv Neuroimmunol. 1996;6(3):249-57. doi: 10.1016/s0960-5428(96)00020-4.

DOI:10.1016/s0960-5428(96)00020-4

PMID:8968424

Abstract

Clinical research has focused on autoimmune disease (AID) for a couple of decades. More sensitive and specific methods have been developed for neuroimmunological research. Gamma fraction bands (bands separated by electrophoresis and visualized by amino black staining) and IgG fraction bands (bands separated by iso-electric focusing and visualized by immunostaining) are used instead of oligoclonal bands. Myasthenia gravis (MG) mainly involves acetylcholine receptors of the postsynaptic membrane at the neuromuscular junction. Myasthenia gravis has been considered to be a generalized AID, because 7% of patients with myasthenia gravis associate with other AIDs and more than one autoimmune antibody is detected in 52.5% patients with myasthenia gravis. Pyramidal signs in myasthenia gravis patients are described; the possible mechanism may at least be partly due to the acetylcholine receptor antibody. P2 protein and its antibody are studied in patients with acute and chronic inflammatory demyelinating polyneuropathy.

摘要

几十年来，临床研究一直聚焦于自身免疫性疾病（AID）。神经免疫学研究已经开发出了更灵敏、更具特异性的方法。使用γ球蛋白区带（通过电泳分离并用氨基黑染色可视化的区带）和IgG组分区带（通过等电聚焦分离并用免疫染色可视化的区带）来替代寡克隆区带。重症肌无力（MG）主要累及神经肌肉接头处突触后膜的乙酰胆碱受体。重症肌无力被认为是一种全身性自身免疫性疾病，因为7%的重症肌无力患者伴有其他自身免疫性疾病，且52.5%的重症肌无力患者检测出不止一种自身免疫抗体。描述了重症肌无力患者的锥体束征；其可能机制至少部分归因于乙酰胆碱受体抗体。对急性和慢性炎症性脱髓鞘性多发性神经病患者的P2蛋白及其抗体进行了研究。