Mitchell C A, Brown S, Campbell J K, Munday A D, Speed C J
Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia.
Biochem Soc Trans. 1996 Nov;24(4):994-1000. doi: 10.1042/bst0240994.
The inositol polyphosphate 5-phosphatases are an enlarging family of enzymes that terminate the signals generated by the phosphoinositide kinases and phospholipase C. Given the diverse signalling functions of both the polyphosphoinositides and Ins(1,4,5)P3, it is predicted that the 5-phosphatases will play a critical role in regulating many cellular events, in particular membrane trafficking and cell growth.
肌醇多磷酸5-磷酸酶是一个不断扩大的酶家族，可终止磷酸肌醇激酶和磷脂酶C产生的信号。鉴于多磷酸肌醇和肌醇-1,4,5-三磷酸（Ins(1,4,5)P3）具有多种信号功能，预计5-磷酸酶在调节许多细胞活动，特别是膜运输和细胞生长中起关键作用。
