Miyashita Y, Koike H, Misawa A, Shimizu H, Yoshida K, Yasutomi T
Department of Internal Medicine, Shiokawa Hospital, Yamanashi.
Intern Med. 1996 Nov;35(11):912-5. doi: 10.2169/internalmedicine.35.912.
A 48-year-old woman with antiphospholipid syndrome (APS) developed pulmonary hypertension without any thromboembolic episode. Multiple pulmonary perfusion defects suggestive of pulmonary thrombosis or in situ thrombosis were observed. Deep venous thrombosis (DVT) of the right femoral vein without symptoms was also detected by contrast venography. Asymptomatic pulmonary hypertension complicated with a hypercoagulable state such as in this case suggests that not only recurrent asymptomatic pulmonary thrombosis, but also in situ thrombosis in pulmonary vessels are possible and important factors in the pathogenesis of pulmonary hypertension.
一名48岁的抗磷脂综合征（APS）女性患者在没有任何血栓栓塞事件的情况下出现了肺动脉高压。观察到多个提示肺血栓形成或原位血栓形成的肺部灌注缺损。经静脉造影还检测到右侧股静脉无症状的深静脉血栓形成（DVT）。如此病例所示，无症状性肺动脉高压合并高凝状态提示，不仅反复发生的无症状性肺血栓形成，而且肺血管原位血栓形成都是肺动脉高压发病机制中可能且重要的因素。
