201铊与99锝-甲氧基异丁基异腈在乳腺肿瘤中的对比研究

[Comparative study of 201Tl and 99mTc-MIBI in breast tumor].

作者信息

Fukumitsu N, Tozaki M, Uchiyama M, Mori Y, Kawakami K, Uchida K

机构信息

Department of Radiology, Jikei University school of Medicine.

出版信息

Nihon Igaku Hoshasen Gakkai Zasshi. 1996 Nov;56(13):974-9.

PMID:8969062

Abstract

A comparative study of 201Tl and 99mTc-MIBI was performed in 39 breast tumors. 201Tl scintigraphy was carried out in 24 breast tumors and 99mTc-MIBI scintigraphy in 15. The sensitivity of 201Tl for malignant tumors was 100% (22/22), but specificity was 0% (0/2). On 99mTc-MIBI scintigraphy, the sensitivity for the malignant tumors was 83.3% (10/12) and specificity was 100% (3/3). 99Tc-MIBI might be more useful for the diagnosis of breast tumors, because the tumor/background ratio of 99mTc-MIBI was significantly higher than that of 201Tl. In addition, 201Tl scintigraphy and 99mTc-MIBI scintigraphy showed the same degree of accuracy (93.3%) in diagnosis of lymph node reached. Moreover, when either US and 201Tl or 99mTc-MIBI scintigraphy was positive for lymph node metastasis, accuracy of detection of lymph node metastasis became 94.4%. A combined study of US and scintigraphy might improve the accuracy for diagnosis of lymph node metastasis.

摘要

对39例乳腺肿瘤进行了201铊（201Tl）和锝-99m-甲氧基异丁基异腈（99mTc-MIBI）的对比研究。24例乳腺肿瘤进行了201Tl闪烁扫描，15例进行了99mTc-MIBI闪烁扫描。201Tl对恶性肿瘤的敏感性为100%（22/22），但特异性为0%（0/2）。在99mTc-MIBI闪烁扫描中，对恶性肿瘤的敏感性为83.3%（10/12），特异性为100%（3/3）。99mTc-MIBI可能对乳腺肿瘤的诊断更有用，因为99mTc-MIBI的肿瘤/本底比值明显高于201Tl。此外，201Tl闪烁扫描和99mTc-MIBI闪烁扫描在诊断腋窝淋巴结转移方面显示出相同的准确性（93.3%）。而且，当超声（US）与201Tl或99mTc-MIBI闪烁扫描对腋窝淋巴结转移均呈阳性时，腋窝淋巴结转移的检测准确性可达94.4%。超声与闪烁扫描的联合研究可能会提高腋窝淋巴结转移诊断的准确性。