豚鼠耳蜗中电诱发耳声发射的频率调谐与声学增强

Frequency tuning and acoustic enhancement of electrically evoked otoacoustic emissions in the guinea pig cochlea.

作者信息

Kirk D L, Yates G K

机构信息

Auditory Laboratory, Department of Physiology, University of Western Australia, Nedlands, Australia.

出版信息

J Acoust Soc Am. 1996 Dec;100(6):3714-25. doi: 10.1121/1.417335.

DOI:10.1121/1.417335

PMID:8969473

Abstract

Electrically evoked otoacoustic emissions (EEOAEs) were generated by ac stimulation in scala media of turns 1, 2, and 3 in the guinea pig cochlea. In each turn EEOAEs were recorded at frequencies up to and slightly above the estimated characteristic frequency (CF) of the stimulation site. Acoustic enhancement of EEOAEs was present at all emission frequencies in turns 2 and 3 but could be demonstrated in turn 1 only at emission frequencies that fell within a notch in the EEOAE tuning function. There was no evidence, in any turn, of a transition from enhancement to suppression as the emission frequency approached the CF of the stimulation site. The results were not consistent with the hypothesis [D. C. Mountain and A. E. Hubbard, Hear, Res. 42, 195-202 (1989)] that acoustic enhancement results from a reduction in the effectiveness of forward transduction in a negative feedback loop.

摘要

通过对豚鼠耳蜗第1、2和3圈的中阶进行交流电刺激来产生电诱发耳声发射（EEOAEs）。在每一圈中，均在高达并略高于刺激部位估计特征频率（CF）的频率下记录EEOAEs。在第2和3圈中，EEOAEs在所有发射频率下均存在声学增强，但仅在EEOAEs调谐函数的一个凹口内的发射频率下，第1圈中才能证明存在声学增强。在任何一圈中，均没有证据表明随着发射频率接近刺激部位的CF，会从增强转变为抑制。这些结果与[D. C. Mountain和A. E. Hubbard，《听觉研究》42，195 - 202（1989）]的假设不一致，该假设认为声学增强是由负反馈回路中正向转导有效性的降低导致的。