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儿童期口服甲氧沙林并联合紫外线A辐射进行治疗会增加患基底细胞癌的风险。PUVA随访研究。

Therapy with orally administered methoxsalen and ultraviolet A radiation during childhood increases the risk of basal cell carcinoma. The PUVA Follow-up Study.

作者信息

Stern R S, Nichols K T

机构信息

Department of Dermatology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

出版信息

J Pediatr. 1996 Dec;129(6):915-7. doi: 10.1016/s0022-3476(96)70039-2.

DOI:10.1016/s0022-3476(96)70039-2
PMID:8969737
Abstract

A child was treated from age 18 months to 8 years with oral methoxsalen and ultraviolet A radiation (PUVA) for refractory psoriasis. Two basal cell cancers developed before age 21 years, suggesting that exposure to PUVA in childhood increases the risk of basal cell cancer.

摘要

一名儿童从18个月大到8岁期间接受口服甲氧沙林和紫外线A辐射(PUVA)治疗顽固性银屑病。在21岁之前出现了两例基底细胞癌,这表明儿童期接触PUVA会增加患基底细胞癌的风险。

相似文献

1
Therapy with orally administered methoxsalen and ultraviolet A radiation during childhood increases the risk of basal cell carcinoma. The PUVA Follow-up Study.儿童期口服甲氧沙林并联合紫外线A辐射进行治疗会增加患基底细胞癌的风险。PUVA随访研究。
J Pediatr. 1996 Dec;129(6):915-7. doi: 10.1016/s0022-3476(96)70039-2.
2
Cancer incidence among Finnish psoriasis patients treated with 8-methoxypsoralen bath PUVA.接受8-甲氧基补骨脂素浴光化学疗法(PUVA)治疗的芬兰银屑病患者的癌症发病率。
J Am Acad Dermatol. 1999 May;40(5 Pt 1):694-6. doi: 10.1016/s0190-9622(99)70148-9.
3
Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study.接受甲氧沙林(补骨脂素)和紫外线A辐射(PUVA)治疗银屑病的患者发生恶性黑色素瘤。PUVA随访研究。
N Engl J Med. 1997 Apr 10;336(15):1041-5. doi: 10.1056/NEJM199704103361501.
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Oral psoralen and ultraviolet-A light (PUVA) treatment of psoriasis and persistent risk of nonmelanoma skin cancer. PUVA Follow-up Study.口服补骨脂素及紫外线A光(PUVA)治疗银屑病与非黑素瘤皮肤癌的持续风险。PUVA随访研究。
J Natl Cancer Inst. 1998 Sep 2;90(17):1278-84. doi: 10.1093/jnci/90.17.1278.
5
PUVA treatment and skin cancer: A follow-up study.补骨脂素加紫外线A光疗法与皮肤癌:一项随访研究。
Acta Derm Venereol. 1981;61(2):141-5.
6
Risks of cancer associated with long-term exposure to PUVA in humans: current status--1991.人类长期暴露于补骨脂素加紫外线A疗法(PUVA)相关的癌症风险:现状——1991年
Blood Cells. 1992;18(1):91-7; discussion 98-9.
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Carcinogenicity of combined ultraviolet B radiation and psoralen plus ultraviolet A irradiation treatment of mice.紫外线B辐射与补骨脂素加紫外线A照射联合治疗小鼠的致癌性。
Photodermatol Photoimmunol Photomed. 1992;9(5):198-202.
8
Cutaneous carcinoma and 8-methoxypsoralen and ultraviolet A (PUVA) lentigines in Japanese patients with psoriasis treated with topical PUVA: a follow-up study of 214 patients.外用补骨脂素加紫外线A(PUVA)治疗的日本银屑病患者的皮肤癌和8-甲氧基补骨脂素与紫外线A(PUVA)所致的雀斑样痣:214例患者的随访研究
Photodermatol Photoimmunol Photomed. 1990 Oct;7(5):218-21.
9
Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation.接受甲氧沙林和紫外线A辐射治疗的患者中的默克尔细胞癌。
N Engl J Med. 1998 Oct 22;339(17):1247-8. doi: 10.1056/NEJM199810223391715.
10
Comparison of the carcinogenic potential of trioxsalen bath PUVA and oral methoxsalen PUVA. A preliminary report.
Arch Dermatol. 1992 Oct;128(10):1341-4. doi: 10.1001/archderm.1992.01680200051005.

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