Law R M, Halpern S, Martins R F, Reich H, Innanen V, Ohlsson A
Department of Pharmacy, Women's College Hospital, Toronto, Ont., Canada.
Biol Neonate. 1996;70(4):213-7. doi: 10.1159/000244367.
A statistically significant (p = 0.049) increase in methemoglobin (MetHb), which did not exceed normal values, was noted 8 h after application of 1 g of EMLA (Eutectic Mixture of Local Anesthetics) to the foreskin of 10 normal newborns to reduce pain associated with circumcision. The highest MetHb concentration observed was 3 g/l (toxic > 50 g/l). No infant showed clinical signs of methemoglobinemia. We conclude that EMLA is safe to use as a local anesthetic in term neonates.
对10名正常新生儿的包皮涂抹1克EMLA（局部麻醉剂的共熔混合物）以减轻包皮环切术相关疼痛后8小时，发现高铁血红蛋白（MetHb）有统计学显著升高（p = 0.049），但未超过正常值。观察到的最高MetHb浓度为3克/升（中毒> 50克/升）。没有婴儿出现高铁血红蛋白血症的临床症状。我们得出结论，EMLA作为足月新生儿的局部麻醉剂使用是安全的。
