Päth G, Bornstein S R, Späth-Schwalbe E, Scherbaum W A
Department of Internal Medicine III, University of Leipzig, Germany.
Endocr Res. 1996 Nov;22(4):867-73. doi: 10.1080/07435809609043788.
Interleukin-6 (IL-6), which is expressed in the human adrenal gland, was found to be a very potent activator of the human HPA axis. So far nothing is known about a local paracrine or autocrine influence of IL-6 within the human adrenal. In this study, the expression of IL-6 and the IL-6 receptor by human adrenal cells in vitro could be demonstrated by immunohistochemistry. Possible effects of IL-6 on steroid release were tested by incubating human adrenal cells in vitro with IL-6 [10(-8) M]. Adrenal steroids were stimulated by IL-6: aldosterone 184 +/- 23, cortisol 198 +/- 19, DHEA 140 +/- 8 and androstenedione 136 +/- 5 (results are means +/- s.e.m. in %). In conclusion, IL-6 can act directly on human adrenal cells and appears to be an important paracrine or autocrine factor.
白细胞介素-6（IL-6）在人肾上腺中表达，被发现是人类下丘脑-垂体-肾上腺（HPA）轴的一种非常有效的激活剂。迄今为止，关于IL-6在人肾上腺内的局部旁分泌或自分泌影响尚不清楚。在本研究中，通过免疫组织化学可证明人肾上腺细胞在体外表达IL-6和IL-6受体。通过在体外将人肾上腺细胞与IL-6[10(-8)M]孵育来测试IL-6对类固醇释放的可能影响。IL-6刺激肾上腺类固醇分泌：醛固酮184±23、皮质醇198±19、脱氢表雄酮140±8和雄烯二酮136±5（结果为平均值±标准误，以%表示）。总之，IL-6可直接作用于人肾上腺细胞，似乎是一种重要的旁分泌或自分泌因子。
