Gonzalez-Hernandez J A, Bornstein S R, Ehrhart-Bornstein M, Späth-Schwalbe E, Jirikowski G, Scherbaum W A
Medizinische Klinik III, Universität Leipzig, Abteilung für Innere Medizin III, Ulm, Germany.
J Clin Endocrinol Metab. 1994 Nov;79(5):1492-7. doi: 10.1210/jcem.79.5.7962348.
Interleukin-6 (IL-6) is an important mediator in the interaction of the hypothalamo-pituitary-adrenal axis with the immune system. Recently, a direct influence of IL-6 on adrenal steroidogenesis has been demonstrated. Therefore, we designed a study to determine whether IL-6 is expressed within the normal human adrenal gland. The combination of in situ hybridization and specific immunostaining was eminently suited to identify the cell types producing IL-6. IL-6 messenger ribonucleic acid occurred in the inner zone of the adrenal cortex in anti-17 alpha-hydroxylase-positive steroid cells. Also, CD68-positive macrophages in the zona reticularis showed a positive signal. No reaction was seen in chromaffin cells. We conclude that under normal conditions, IL-6 is expressed in specialized adrenocortical cells. Therefore, IL-6 may play an important role as a paracrine or autocrine factor in a local immune-adrenal interaction.
白细胞介素-6（IL-6）是下丘脑-垂体-肾上腺轴与免疫系统相互作用中的重要介质。最近，已证实IL-6对肾上腺类固醇生成有直接影响。因此，我们设计了一项研究来确定IL-6是否在正常人体肾上腺中表达。原位杂交和特异性免疫染色相结合非常适合鉴定产生IL-6的细胞类型。IL-6信使核糖核酸出现在肾上腺皮质内层抗17α-羟化酶阳性的类固醇细胞中。此外，网状带中的CD68阳性巨噬细胞显示出阳性信号。嗜铬细胞中未见反应。我们得出结论，在正常情况下，IL-6在特化的肾上腺皮质细胞中表达。因此，IL-6可能作为旁分泌或自分泌因子在局部免疫-肾上腺相互作用中发挥重要作用。
