Schmid A, Jakob E, Berg A, Russmann T, König D, Irmer M, Keul J
University of Freiburg, Department of Physical Performance Medicine, Germany.
Med Sci Sports Exerc. 1996 Dec;28(12):1470-3. doi: 10.1097/00005768-199612000-00005.
The effect of physical exercise and vitamin C on iron absorption after oral iron administration was investigated. Eight healthy male subjects without iron deficiency were studied after administration of 100 mg ferric sodium citrate complex, 100 mg ferric sodium citrate complex with 200 mg ascorbic acid, and without iron intake, both under resting conditions and after a 1-h bicycle ergometer test at moderate exercise. Serum concentrations for iron, transferrin, and ferritin were measured before and 30 min, and 1, 2, and 4 h after each administration. Under resting conditions administration of 100 mg ferric sodium citrate led to a significant increase in serum iron concentrations. When ferric sodium citrate was administered with vitamin C, iron values increased significantly further. Ingestion of iron together with physical exercise resulted in a higher serum iron concentration than under resting conditions. The maximum increase, reached after 4 h, was 48.2% with exercise and 8.3% without. In combination with exercise, the addition of 200 mg vitamin C did not further increase serum iron concentration. In conclusion, 1 h of moderate exercise enhanced the rate of iron absorption. Under resting conditions the combination of ferric sodium citrate with vitamin C led to significantly increased postabsorption serum iron concentrations compared with iron administration without vitamin C.
研究了体育锻炼和维生素C对口服铁剂后铁吸收的影响。对8名无缺铁的健康男性受试者进行了研究，在静息状态下以及在进行1小时中等强度自行车测力计测试后，分别给予100毫克柠檬酸铁钠复合物、100毫克柠檬酸铁钠复合物加200毫克抗坏血酸，以及不摄入铁剂。在每次给药前、给药后30分钟、1小时、2小时和4小时测量血清铁、转铁蛋白和铁蛋白的浓度。在静息状态下，给予100毫克柠檬酸铁钠导致血清铁浓度显著升高。当柠檬酸铁钠与维生素C一起给药时，铁值进一步显著升高。与静息状态相比，铁剂与体育锻炼同时摄入会导致更高的血清铁浓度。4小时后达到的最大增幅，锻炼组为48.2%，非锻炼组为8.3%。与锻炼相结合时，添加200毫克维生素C并未进一步提高血清铁浓度。总之，1小时的中等强度锻炼提高了铁的吸收率。在静息状态下，与不添加维生素C的铁剂给药相比，柠檬酸铁钠与维生素C联合使用导致吸收后血清铁浓度显著升高。
