Pfeffer S R
Department of Biochemistry, Stanford University School of Medicine, California 94305-5307, USA.
Annu Rev Cell Dev Biol. 1996;12:441-61. doi: 10.1146/annurev.cellbio.12.1.441.
Proteins that function in transport vesicle docking are being identified at a rapid rate. So-called v- and t-SNAREs form the core of a vesicle docking complex. Additional accessory proteins are required to protect SNAREs from promiscuous binding and to deprotect SNAREs under conditions in which transport vesicle docking should occur. Because access to SNAREs must be regulated, other proteins must also contain specificity determinants to accomplish delivery of transport vesicles to their distinct and specific membrane targets.
在运输小泡对接过程中发挥作用的蛋白质正以很快的速度被鉴定出来。所谓的v-SNARE和t-SNARE构成了小泡对接复合体的核心。还需要其他辅助蛋白来保护SNAREs不发生杂乱结合，并在运输小泡对接应该发生的条件下使SNAREs去保护化。由于必须对SNAREs的可及性进行调控，其他蛋白质也必须包含特异性决定因素，以实现将运输小泡递送至其不同且特定的膜靶标。
