人巨细胞病毒感染在多个环节抑制细胞周期进程，包括从G1期到S期的转变。
Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S.
作者信息
Lu M, Shenk T
机构信息
Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544-1014, USA.
出版信息
J Virol. 1996 Dec;70(12):8850-7. doi: 10.1128/JVI.70.12.8850-8857.1996.
Abstract
Human cytomegalovirus inhibits the growth of human foreskin fibroblast cells by 12 h after infection. Analysis of the cellular DNA content of infected cells by flow cytometry demonstrated that cytomegalovirus does not arrest cell cycle progression at a single point. At least two blockages occur, one of which is in the G1 phase of the cell cycle. The G1 arrest introduced by cytomegalovirus infection blocks S-phase entry after serum stimulation.
摘要
人巨细胞病毒感染12小时后会抑制人包皮成纤维细胞的生长。通过流式细胞术分析受感染细胞的细胞DNA含量表明，巨细胞病毒不会在单一时间点阻止细胞周期进程。至少会出现两种阻滞，其中一种发生在细胞周期的G1期。巨细胞病毒感染引起的G1期阻滞会在血清刺激后阻止细胞进入S期。
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