Migliore M, Alicata F, Ayala G F
Institute for Interdisciplinary Applications of Physics, National Research Council, Palermo, Italy.
Biosystems. 1997;40(1-2):127-32. doi: 10.1016/0303-2647(96)01638-3.
There are still no clear biophysical models for Associative Long-Term Potentiation (LTP) and Depression (LTD) in the hippocampus, where two populations of synapses targeted to the same receptive field are involved. Here we propose a model that allows an interpretation of the experiments in terms of the molecular processes that may be involved in associative memory. The model suggests that retrograde messengers could have a critical role in the induction and maintenance of associative LTP and LTD, by controlling the coupling between the two populations of synapses.
对于海马体中涉及针对同一感受野的两类突触群的联合性长时程增强（LTP）和长时程抑制（LTD），目前仍没有清晰的生物物理模型。在此，我们提出一个模型，该模型能依据可能参与联合性记忆的分子过程来解释相关实验。该模型表明，逆行信使可能在联合性LTP和LTD的诱导及维持过程中发挥关键作用，其作用方式是控制这两类突触群之间的耦合。
