Glogowska-Szelag J, Plewka A, Kamiński M, Górski J, Kajdaniuk D, Nowak M, Buntner B
2nd Department of Histology and Embryology, Silesian School of Medicine, Katowice-Ligota, Poland.
Folia Biol (Praha). 1996;42(3):113-5.
Young female Wistar rats were injected intraperitoneally with increasing doses of morphine (9-45 mg/kg b.w. twice a day) for 14 days. The activities of the cytochrome P-450-dependent monooxygenase system and microsomal electron transport chain I were determined. Long-term morphine treatment decreased significantly cytochrome P-450 content, while it did not affect microsomal electron transport chain I. A decrease in cytochrome b5 content was accompanied by a compensatory increase in the activity of NADH-cytochrome b5 reductase. Both 4-aminopyrine N-demethylase activity and aniline hydroxylase activity decreased after morphine treatment (48% and 70%, respectively, when compared with controls).
将年轻雌性Wistar大鼠腹腔注射递增剂量的吗啡（9 - 45毫克/千克体重，每天两次），持续14天。测定细胞色素P - 450依赖的单加氧酶系统和微粒体电子传递链I的活性。长期吗啡治疗显著降低了细胞色素P - 450的含量，但对微粒体电子传递链I没有影响。细胞色素b5含量的降低伴随着NADH - 细胞色素b5还原酶活性的代偿性增加。吗啡治疗后，4 - 氨基吡啶N - 脱甲基酶活性和苯胺羟化酶活性均降低（与对照组相比，分别降低了48%和70%）。
