Laheij R J, Jansen J B, van de Lisdonk E H, Severens J L, Verbeek A L
Department of Gastroenterology, University Hospital, Nijmegen, The Netherlands.
Aliment Pharmacol Ther. 1996 Dec;10(6):843-50. doi: 10.1046/j.1365-2036.1996.86258000.x.
The aim of this article is to determine, by reviewing the literature, whether treatment of Helicobacter pylori infection in patients with non-ulcer dyspepsia affects symptoms. Ten publications were identified through a computerized and manual literature search, and the percentage of patients with symptom improvement after successful or unsuccessful eradication therapy for H. pylori infection was calculated. In the 10 studies, symptom improvement after treatment was found in 73% of the patients that became H. pylori-negative and 45% of the patients that remained H. pylori-positive. Symptom improvement was modified by various clinical features and methodological aspects. If eradication of H. pylori failed, symptoms only improved over a short period. Symptom improvement was more pronounced in dyspeptic patients in whom H. pylori was eradicated than in those in whom H. pylori infection persisted.
本文的目的是通过回顾文献来确定，对非溃疡性消化不良患者进行幽门螺杆菌感染治疗是否会影响症状。通过计算机化和人工文献检索确定了10篇出版物，并计算了幽门螺杆菌感染根除治疗成功或失败后症状改善的患者百分比。在这10项研究中，幽门螺杆菌转阴的患者中有73%症状得到改善，幽门螺杆菌仍为阳性的患者中有45%症状得到改善。症状改善受到各种临床特征和方法学方面的影响。如果幽门螺杆菌根除失败，症状仅在短期内有所改善。与幽门螺杆菌感染持续存在的消化不良患者相比，幽门螺杆菌被根除的消化不良患者症状改善更为明显。
