Stacher G, Schneider C, Steinringer H, Satzinger U, Weber U
Department of Surgery, University of Vienna, Wien, Austria.
Aliment Pharmacol Ther. 1996 Dec;10(6):883-8. doi: 10.1046/j.1365-2036.1996.102274000.x.
Nitric oxide plays an important role in the control of gastrointestinal motility. This study assessed the effects of graded doses of the nitric oxide-releasing agent, nitroglycerine, on distal oesophageal motor activity and lower oesophageal sphincter resting pressure.
Eight healthy young men received at 1-week intervals placebo, 0.2 mg, 0.4 mg or 0.8 mg nitroglycerine sublingually under random double-blind conditions. Sphincter pressure was recorded using a Dent sleeve and oesophageal motility using sensors 1, 4, 7 and 10 cm orad the sleeve during two 15-min periods before and four 15-min periods after drug administration. In minutes 4 to 6 of each period, subjects swallowed 5 mL water at 30 s intervals.
After 0.2 mg and 0.4 mg nitroglycerine, amplitude, duration and area under curve of swallow-initiated contractions were smaller than after placebo. After 0.8 mg nitroglycerine, amplitude, duration and area under curve were slightly greater than after placebo and significantly greater than after the lower nitroglycerine doses. No effects were discernible on onset latency and propagation velocity of contractions as well as on lower oesophageal sphincter resting pressure.
Sublingual nitroglycerine had modest, dose-dependent effects on oesophageal peristaltic amplitude and duration, but did not affect the tone of the lower oesophageal sphincter.
一氧化氮在胃肠道运动控制中起重要作用。本研究评估了不同剂量的一氧化氮释放剂硝酸甘油对食管远端运动活性及食管下括约肌静息压力的影响。
8名健康年轻男性在随机双盲条件下，每隔1周舌下含服安慰剂、0.2毫克、0.4毫克或0.8毫克硝酸甘油。在给药前两个15分钟时段及给药后四个15分钟时段，使用Dent套管记录括约肌压力，使用位于套管口上1、4、7和10厘米处的传感器记录食管运动。在每个时段的第4至6分钟，受试者每隔30秒吞咽5毫升水。
服用0.2毫克和0.4毫克硝酸甘油后，吞咽引发收缩的幅度、持续时间和曲线下面积均小于服用安慰剂后。服用0.8毫克硝酸甘油后，幅度、持续时间和曲线下面积略大于服用安慰剂后，且显著大于较低剂量硝酸甘油后的水平。对收缩的起始潜伏期、传播速度以及食管下括约肌静息压力均无明显影响。
舌下含服硝酸甘油对食管蠕动幅度和持续时间有适度的剂量依赖性影响，但不影响食管下括约肌的张力。
