Wallin L, Boesby S, Madsen T
Scand J Gastroenterol. 1979;14(8):923-7.
The aim of the present study was to measure the amplitude, the duration, and the velocity of the peristaltic pressure wave in the lower part of the oesophagus in the basal state and at different time intervals after oral intake of 10 and 20 mg metoclopramide. In addition, gastro-oesophageal sphincter pressure was measured in the basal state and 90 min after the intake of metoclopramide. The pressure studies were carried out in eight healthy subjects, using a pressure probe consisting of two open-tip polyethylene catheters that were fed by a capillary tubular system and connected to external pressure transducers. Sphincter pressure was measured (intermittent withdrawal), and the probe was positioned with the distal opening 5 cm orally to the sphincter. Dry and wet (bolus, 5 ml of water) swallows were made in randomized order in the basal state and at the time intervals after the intake of metoclopramide. Finally, the sphincter pressure measurement was repeated. No differences were seen with regard to the peristaltic activity: amplitude, duration, or velocity. Sphincter pressure rose from 12 to 19 mmHg after 10 mg (p less than 0.05) and from 13 to 20 mmHg after 20 mg metoclopramide (p less than 0.05). There were no significant differences between basal values and the response to 10 or 20 mg metoclopramide.
本研究的目的是测量基础状态下以及口服10毫克和20毫克胃复安后不同时间间隔时食管下部蠕动压力波的幅度、持续时间和速度。此外，还测量了基础状态下以及服用胃复安90分钟后的胃食管括约肌压力。压力研究在8名健康受试者中进行，使用由两根开放式聚乙烯导管组成的压力探头，该探头由毛细管系统供液并连接到外部压力传感器。测量括约肌压力（间歇性回撤），探头定位时其远端开口位于括约肌上方5厘米处。在基础状态下以及服用胃复安后的各个时间间隔，随机进行干咽和湿咽（吞咽5毫升水）。最后，重复测量括约肌压力。在蠕动活动方面未见差异：幅度、持续时间或速度。服用10毫克胃复安后括约肌压力从12毫米汞柱升至19毫米汞柱（p<0.05），服用20毫克胃复安后从13毫米汞柱升至20毫米汞柱（p<0.05）。基础值与对10毫克或20毫克胃复安的反应之间无显著差异。
