Cool V A
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
Bone Marrow Transplant. 1996 Dec;18 Suppl 3:S45-9.
While research has documented neuropsychological sequelae following cranial radiation and chemotherapy for childhood cancer, little is known about the effects of the BMT process on the neuropsychological functioning of children. Results from ongoing studies at The University of Iowa indicate that at pre-BMT evaluations, children who have had prior CRT already show signs of declining IQ scores and below average academic achievement. By 4 years post-BMT, there is evidence of declining IQ, achievement, memory, and fine motor skills. Risk factors appear to be younger age at diagnosis and CRT prior to BMT but additional research is needed.
虽然研究已经记录了儿童癌症患者接受头颅放疗和化疗后的神经心理学后遗症，但对于骨髓移植（BMT）过程对儿童神经心理功能的影响却知之甚少。爱荷华大学正在进行的研究结果表明，在BMT前评估时，之前接受过颅脑放疗（CRT）的儿童已经显示出智商分数下降和学业成绩低于平均水平的迹象。到BMT后4年，有证据表明智商、学业成绩、记忆力和精细运动技能都在下降。风险因素似乎是诊断时年龄较小以及在BMT前接受过CRT，但还需要更多的研究。
