Simms S, Kazak A E, Gannon T, Goldwein J, Bunin N
Division of Oncology, The Children's Hospital of Philadelphia, PA 19104-4399, USA.
Bone Marrow Transplant. 1998 Jul;22(2):181-4. doi: 10.1038/sj.bmt.1701295.
The purpose of the study was to prospectively evaluate the neuropsychological functioning of children and adolescents receiving a bone marrow transplant (BMT). One hundred and twenty-two children with malignant or nonmalignant disorders and no previous cranial radiation therapy received a pre-BMT neuropsychological evaluation. Surviving children received a 1 year post-BMT neuropsychological evaluation. Patients were placed in a chemotherapy only (chemo) or a chemotherapy and total body irradiation (chemo + TBI) group for statistical analysis. The data were analyzed by t-tests for paired samples. There were no statistically significant differences. Regression analysis failed to identify treatment, age and gender effects. The results suggest that global and specific areas of neuropsychological functioning 1 year post-BMT were not detrimentally affected by chemotherapy or chemotherapy with total body irradiation.
本研究的目的是前瞻性评估接受骨髓移植（BMT）的儿童和青少年的神经心理功能。122名患有恶性或非恶性疾病且既往未接受过颅脑放射治疗的儿童接受了BMT前的神经心理评估。存活的儿童在BMT后1年接受了神经心理评估。将患者分为单纯化疗组（化疗组）或化疗加全身照射组（化疗+TBI组）进行统计分析。数据采用配对样本t检验进行分析。未发现统计学上的显著差异。回归分析未能确定治疗、年龄和性别效应。结果表明，BMT后1年神经心理功能的整体和特定领域未受到化疗或化疗加全身照射的不利影响。
