新型全氟碳玻璃体替代物Multifluor APF-144的玻璃体内耐受性
Intravitreal tolerance of a new perfluorocarbon vitreous replacement, Multifluor APF-144.
作者信息
Peyman G A, Soheilian M, Luo Q, Moshfeghi D, Schweighardt F K
机构信息
LSU Eye Center, Louisiana State University Medical, Center School of Medicine, New Orleans 70112-2234, USA.
出版信息
Can J Ophthalmol. 1996 Dec;31(7):345-9.
OBJECTIVE
To evaluate the intravitreal tolerance of a new perfluorocarbon vitreous replacement, Multifluor APF-144 (perfluorotetramethylcyclohexane).
DESIGN
Ten New Zealand albino rabbits (one eye from each) underwent vitrectomy. The vitreous was replaced in five eyes with Multifluor APF-144 and in five eyes with saline (control group).
OUTCOME MEASURES
Appearance on indirect ophthalmoscopy, electroretinography recordings before and 2, 4 and 8 weeks after vitrectomy, findings on electron and light microscopy at 8 weeks.
RESULTS
Endophthalmitis did not develop in any of the eyes. There was no significant change in electroretinography values for the experimental eyes after vitrectomy. No evidence of retinal toxicity was found on light or electron microscopic examination.
CONCLUSIONS
Multifluor APF-144 shows promise as a short-term postoperative retinal tamponading agent.
目的
评估新型全氟碳玻璃体替代物Multifluor APF - 144（全氟四甲基环己烷）的玻璃体内耐受性。
设计
十只新西兰白化兔（每只一只眼）接受玻璃体切除术。五只眼用Multifluor APF - 144替代玻璃体，另外五只眼用生理盐水替代（对照组）。
观察指标
间接检眼镜检查外观、玻璃体切除术前以及术后2周、4周和8周的视网膜电图记录、8周时电子显微镜和光学显微镜检查结果。
结果
所有眼中均未发生眼内炎。玻璃体切除术后，实验眼的视网膜电图值无显著变化。光学显微镜或电子显微镜检查均未发现视网膜毒性证据。
结论
Multifluor APF - 144有望作为术后短期视网膜填塞剂。
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