Flores-Aguilar M, Munguia D, Loeb E, Crapotta J A, Vuong C, Shakiba S, Bergeron-Lynn G, Wiley C A, Weers J, Freeman W R
Department of Ophthalmology, University of California, San Diego, USA.
Retina. 1995;15(1):3-13.
To determine the intraocular tolerance of perfluorooctylbromide (perflubron) in vitrectomized rabbit and pig eyes and evaluated its use as a vitreous substitute in virteoretinal surgery.
Pars plana vitrectomy was performed on 33 Dutch pigmented rabbits and 11 micro mini pigs. After vitrectomy the eyes were filled with perflubron for 2 hours, 1 week, 2 weeks, 1 month, and up to 6 months.
No clinical, electroretinographic, or light and electron microscopic evidence of adverse effects on the retina and lens were observed. Perflubron emulsified and dispersed into small bubbles after 2-3 weeks. The lens showed mild posterior subcapsular cataracts in pig eyes after long-term retention of perflubron.
These findings indicate that perflubron is safe for intraoperative and for long-term use intravitreally. However, emulsification and the breakdown into small bubbles limits the view of the retina when perflubron is used as a long-term tamponade.
确定全氟辛基溴（全氟溴辛烷）在玻璃体切除的兔眼和猪眼中的眼内耐受性，并评估其在玻璃体视网膜手术中作为玻璃体替代物的用途。
对33只荷兰有色兔和11只微型猪进行了扁平部玻璃体切除术。玻璃体切除术后，用全氟溴辛烷填充眼睛达2小时、1周、2周、1个月及长达6个月之久。
未观察到对视网膜和晶状体产生不良反应的临床、视网膜电图或光镜及电镜证据。2至3周后，全氟溴辛烷乳化并分散成小气泡。在长期保留全氟溴辛烷后，猪眼中的晶状体出现轻度后囊下白内障。
这些发现表明，全氟溴辛烷在眼内用于术中及长期使用是安全的。然而，当全氟溴辛烷用作长期填塞物时，其乳化和分解成小气泡会限制对视网膜的观察。
