Pasparakis M, Alexopoulou L, Douni E, Kollias G
Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece.
Cytokine Growth Factor Rev. 1996 Oct;7(3):223-9. doi: 10.1016/s1359-6101(96)00031-7.
Tumour necrosis factors have been classically studied as molecules central to the pathogenesis of infectious, inflammatory and autoimmune diseases. The recent generation of mice deficient in TNF alpha, LT alpha, or their receptors, has provided exciting new insights into the physiological role of these molecules in the development of secondary lymphoid tissues and in the organisation of the humoral immune response.
肿瘤坏死因子一直被作为感染性、炎症性和自身免疫性疾病发病机制的核心分子进行经典研究。最近培育出的缺乏肿瘤坏死因子α、淋巴毒素α或其受体的小鼠，为这些分子在次级淋巴组织发育和体液免疫反应组织中的生理作用提供了令人兴奋的新见解。
