Koo C H, Shin S S, Bracho F, Johnston W H, Rappaport H
Department of Pathology, Kaiser Foundation Hospital, Los Angeles, California, USA.
Histopathology. 1996 Dec;29(6):557-63. doi: 10.1046/j.1365-2559.1996.d01-530.x.
Homer Wright rosettes, typically found in neuroblastomas and consisting of neoplastic cells surrounding an eosinophilic fibrillary centre without a lumen, have been considered as an important finding in the differential diagnosis of small round cell tumours. Rosettes in a neoplasm involving lymph nodes or bone marrow traditionally excluded a diagnosis of malignant lymphoma. In this report, we describe three cases of malignant lymphoma (two small lymphocytic and one diffuse large cell) with pronounced rosette formation. One of the two cases of small lymphocytic lymphoma was observed in the bone marrow, the other small lymphocytic lymphoma and the large cell lymphoma were in lymph nodes. The rosettes consisted of neoplastic lymphoid cells, often with participation of reactive macrophages, and ultrastructurally they had a central mass of interdigitating fibrillary cytoplasmic projections. Two cases were of B-cell lineage and one was of T-cell lineage. To the best of our knowledge, this is the first report of T-cell lymphoma with rosettes. Based on these findings, it is suggested that non-Hodgkin's lymphoma be included in the differential diagnosis of rosette-forming round cell neoplasms.
霍纳氏（Homer Wright）玫瑰花结通常见于神经母细胞瘤，由围绕嗜酸性纤维性中心且无管腔的肿瘤细胞组成，一直被视为小圆细胞肿瘤鉴别诊断中的一项重要发现。肿瘤累及淋巴结或骨髓时出现的玫瑰花结传统上排除了恶性淋巴瘤的诊断。在本报告中，我们描述了3例具有明显玫瑰花结形成的恶性淋巴瘤（2例小淋巴细胞性和1例弥漫大细胞性）。2例小淋巴细胞性淋巴瘤中的1例见于骨髓，另1例小淋巴细胞性淋巴瘤和大细胞淋巴瘤位于淋巴结。玫瑰花结由肿瘤性淋巴细胞组成，常伴有反应性巨噬细胞参与，超微结构显示它们有一个由相互交错的纤维性胞质突起构成的中央团块。2例为B细胞谱系，1例为T细胞谱系。据我们所知，这是关于伴有玫瑰花结的T细胞淋巴瘤的首次报告。基于这些发现，提示非霍奇金淋巴瘤应纳入形成玫瑰花结的圆形细胞肿瘤的鉴别诊断中。
