Franco V, Florena A M, Campesi G
Istituto di Anatomia ed Istologia Patologica, University of Palermo, Italy.
Histopathology. 1996 Dec;29(6):571-5. doi: 10.1046/j.1365-2559.1996.d01-536.x.
A particular type of lymphomatous bone marrow infiltration defined as intrasinusoidal and occurring in seven patients with splenomegaly and mild to moderate thrombocytopenia is reported. Immunocytochemistry highlighted the intrasinusoidal pattern and showed a mature B-cell phenotype. Four patients underwent splenectomy and a diagnosis of splenic marginal cell lymphoma was made. The disease course seems to be chronic and quite indolent. All patients are alive and well; follow-up ranges from 2 to 42 months. The value of bone marrow biopsy as a primary diagnostic tool in splenic marginal zone lymphomas is discussed.
报告了一种特殊类型的淋巴瘤性骨髓浸润，其定义为窦内浸润，发生在7例脾肿大和轻度至中度血小板减少的患者中。免疫细胞化学突出了窦内模式，并显示为成熟B细胞表型。4例患者接受了脾切除术，诊断为脾边缘区淋巴瘤。疾病进程似乎是慢性且相当惰性的。所有患者均存活且状况良好；随访时间为2至42个月。讨论了骨髓活检作为脾边缘区淋巴瘤主要诊断工具的价值。
