Bonometti Arturo, Tzankov Alexander, Alborelli Ilaria, Russkamp Norman F, Dertinger Susanne, Dirnhofer Stefan
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090, Milan, Italy.
Pathology Unit, Humanitas Clinical and Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy.
Virchows Arch. 2025 Mar;486(3):563-572. doi: 10.1007/s00428-024-03885-7. Epub 2024 Aug 6.
Intrasinusoidal bone marrow involvement is an infrequent histological pattern observed in a limited number of B and T cell lymphomas. Mantle cell lymphoma is a biologically and prognostically heterogeneous B cell lymphoma that frequently involves the bone marrow, with interstitial, nodular-paratrabecular, or diffuse patterns. Intrasinusoidal bone marrow involvement has been described only anecdotally in this lymphoma. Here, we describe the clinical, histopathological, and molecular features of four patients diagnosed with advanced-stage mantle cell lymphoma, showing intrasinusoidal bone marrow involvement, and other peculiar immunophenotypical features. As similar cases may represent a relevant issue in bone marrow diagnostic histopathology, we also reviewed the literature to discuss differential diagnoses of B and T cell lymphomas with intrasinusoidal bone marrow involvement.
窦内骨髓受累是在少数B细胞和T细胞淋巴瘤中观察到的一种罕见组织学模式。套细胞淋巴瘤是一种生物学和预后异质性的B细胞淋巴瘤，常累及骨髓，表现为间质、结节旁小梁或弥漫性模式。窦内骨髓受累在这种淋巴瘤中仅有零星报道。在此，我们描述了4例诊断为晚期套细胞淋巴瘤患者的临床、组织病理学和分子特征，这些患者表现为窦内骨髓受累及其他特殊的免疫表型特征。由于类似病例可能是骨髓诊断组织病理学中的一个相关问题，我们还回顾了文献，以讨论伴有窦内骨髓受累的B细胞和T细胞淋巴瘤的鉴别诊断。
