Seko Y, Azuma M, Yagita H, Okumura K, Yazaki Y
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Int Angiol. 1996 Sep;15(3):245-8.
Here we report a rare case of T-cell prolymphocytic leukemia in which leukemic killer cells, expressing a cytolytic factor perforin, infiltrated the aorta as well as the heart and may have directly injured aortic vascular cells which strongly expressed human leukocyte antigens (HLAs) and intercellular adhesion molecule-1 (ICAM-1) as well as costimulatory molecules B7 and B70, which are ligands for CD28 expressed on T-cells. In spite of chemotherapy against leukemic cells, this autoimmune process finally caused fatal multi-organ failure.
在此，我们报告一例罕见的T细胞原淋巴细胞白血病病例，其中表达溶细胞因子穿孔素的白血病杀伤细胞浸润了主动脉以及心脏，可能直接损伤了强烈表达人类白细胞抗原（HLA）、细胞间黏附分子-1（ICAM-1）以及共刺激分子B7和B70的主动脉血管细胞，这些分子是T细胞上表达的CD28的配体。尽管针对白血病细胞进行了化疗，但这种自身免疫过程最终导致了致命的多器官衰竭。
