Piercey M F, Walker E L, Feldpausch D L, Camacho-Ochoa M
CNS Research 7251-209-419 Pharmacia and Upjohn Inc., Kalamazoo, MI 49001, USA.
Neurosci Lett. 1996 Nov 22;219(2):138-40.
Quantitative autoradiography of rat brain slices was carried out with eight concentrations of [3H]pramipexole, a dopamine D3 receptor-preferring ligand. Saturation analysis revealed high affinity pramipexole binding (Kd = 0.2-0.4 nM) in the islets of Calleja, nucleus accumbens, olfactory tubercle, and anterior caudate. Since these affinities resemble pramipexole's affinity for the high affinity state of the rat dopamine D3, but not D2 receptors, it is possible that dopamine D3 receptors have greater presence in caudate than has heretofore been appreciated.
采用八种浓度的[3H]普拉克索（一种对多巴胺D3受体具有选择性的配体）对大鼠脑切片进行定量放射自显影。饱和分析显示，在Calleja岛、伏隔核、嗅结节和前尾状核中存在高亲和力的普拉克索结合（解离常数Kd = 0.2 - 0.4 nM）。由于这些亲和力类似于普拉克索对大鼠多巴胺D3而非D2受体高亲和力状态的亲和力，因此尾状核中多巴胺D3受体的存在可能比迄今所认识到的更为广泛。
