Huang P P, Zagzag D, Benjamin V
Department of Neurosurgery, New York University Medical Center, New York, USA.
Neurosurgery. 1997 Jan;40(1):194-7. doi: 10.1097/00006123-199701000-00043.
Intracerebral schwannomas not associated with cranial nerves account for less than 1% of surgically treated schwannomas of the central and peripheral nervous system. Subfrontal schwannomas are extremely rare, with only 15 cases reported to date.
A 33-year-old man presented with a 4-month history of progressive headaches and lethargy. Radiographic studies revealed a large subfrontal tumor thought to be a meningioma preoperatively.
The patient underwent a craniotomy for resection of his tumor. Intraoperatively, a large extra-axial tumor arising from the floor of the left frontal fossa was encountered.
Microscopic examination of the tumor revealed a schwannoma. Several theories on the possible origin of intracerebral schwannomas have been considered. Because of the age of the patient at presentation, many authors have postulated a developmental origin for these lesions. However, extra-axial schwannomas not associated with cranial nerves often present later in life, suggesting a different pathogenesis for this subgroup.
与颅神经无关的脑内神经鞘瘤占中枢和周围神经系统手术治疗的神经鞘瘤的比例不到1%。额下神经鞘瘤极为罕见,迄今为止仅报道过15例。
一名33岁男性,有4个月进行性头痛和嗜睡病史。影像学检查显示术前认为是脑膜瘤的巨大额下肿瘤。
患者接受了开颅肿瘤切除术。术中,发现一个起源于左侧额叶窝底部的巨大轴外肿瘤。
肿瘤的显微镜检查显示为神经鞘瘤。已经考虑了关于脑内神经鞘瘤可能起源的几种理论。由于患者发病时的年龄,许多作者推测这些病变起源于发育异常。然而,与颅神经无关的轴外神经鞘瘤通常在生命后期出现,提示该亚组有不同的发病机制。