Synthesis and preliminary evaluation of (S)-(2-[18F]fluoro-4,5-dihydroxyphenyl)-2-methyl L-alanine, (S)-[18F]-FMEDOPA, a potentially improved imaging agent for the presynaptic dopaminergic nervous system.
作者信息
Yost Y, Conway T
机构信息
PET Imaging Service, Veterans Administration Medical Center, Minneapolis, MN 55417, USA.
出版信息
Nucl Med Biol. 1996 Oct;23(7):857-65. doi: 10.1016/s0969-8051(96)00056-x.
PMID:8971852
Abstract
The synthesis and preliminary rat biodistribution studies of (S)-(2-[18F]fluoro-4,5-dihydroxyphenyl)-2-methyl L-alanine, (S)-[18F]-FMEDOPA, a potentially improved imaging agent for the presynaptic dopaminergic nervous system, are reported. (S)-[18F]-FMEDOPA produces a higher striatum-to-cerebellum (S/C) radioactivity ratio than the currently used PET imaging agent, (S)-[18F]-FDOPA, does at 180 min after administration.
摘要
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