Chatterjee M, Majumder A, Iyer P, Muthukrishnan G, Das M K, Ramamoorthy N, Desai C N, Banerjee S
Indian Institute of Chemical Biology, Calcutta, India.
Nucl Med Biol. 1996 Oct;23(7):867-72. doi: 10.1016/s0969-8051(96)00116-3.
Technetium-99m-MAG3 is accepted as a renal tubular function agent. However, sporadic liver and gall bladder visualisation during its clinical use is clearly a disadvantage. HPLC-purified 99mTc-MAG3 samples exhibited appreciable hepatobiliary uptake (7%), and an elevated level of such uptake was observed in unpurified kit preparations, which was stated to be associated with the excretory property of the radiolabeled kit impurities. To verify this we attempted to quantitate the hepatobiliary uptake of the kit preparations with that of its radiolabeled components. The contribution of each component toward hepatobiliary uptake of the sample was calculated from their abundance in the chelate mixture and the individual biodistribution of the isolated components. However, the anticipated hepatobiliary uptake of different preparations of 99mTc-MAG3 calculated in this way was always lower than that of the experimental value determined directly. Further work is needed to explain the anomaly.
锝-99m-巯基乙酰三甘氨酸（Technetium-99m-MAG3）被公认为一种肾小管功能显像剂。然而，在其临床应用过程中偶尔出现肝脏和胆囊显像是一个明显的缺点。经高效液相色谱（HPLC）纯化的99mTc-MAG3样品表现出明显的肝胆摄取（7%），并且在未纯化的试剂盒制剂中观察到这种摄取水平升高，据称这与放射性标记的试剂盒杂质的排泄特性有关。为了验证这一点，我们试图将试剂盒制剂的肝胆摄取与其放射性标记成分的摄取进行定量比较。根据各成分在螯合物混合物中的丰度以及分离成分的个体生物分布，计算出每种成分对样品肝胆摄取的贡献。然而，以这种方式计算的不同制剂的99mTc-MAG3预期肝胆摄取总是低于直接测定的实验值。需要进一步的研究来解释这一异常现象。
