儿童中身长/血清肌酐比值作为肾小球滤过率估计指标的局限性。

Limitations to body length/serum creatinine ratio as an estimate of glomerular filtration in children.

作者信息

Seikaly M G, Browne R, Bajaj G, Arant B S

机构信息

Department of Pediatrics, University of Texas Southwestern Medical Center, USA.

出版信息

Pediatr Nephrol. 1996 Dec;10(6):709-11. doi: 10.1007/s004670050195.

DOI:10.1007/s004670050195

PMID:8971885

Abstract

The ability of the Schwartz formula (CSCH) to estimate glomerular filtration rate (GFR) accurately was investigated in children with renal disease. 125Iodine-iothalamate clearance (CIO) was used as the reference standard for measuring GFR. Data from 176 CIO studies performed on 133 children (aged between 1 and 18 years) were compared with the simultaneous estimation of GFR by CSCH. The overestimation of GFR by CSCH was inversely proportional to the level of renal function. When CIO was > 90 ml/min per 1.73 m2, CSCH overestimated GFR by only 0.1% +/- 3%, but when CIO was < or = 15 ml/min per 1.73 m2, CSCH overestimated GFR by 164% +/- 42%. When renal function is normal or mildly reduced (GFR > 50 ml/min per 1.73 m2), CSCH overestimated CIO by only 10.3 +/- 3.0%, compared with 90.3 +/- 14.5% when renal function was moderately to severely curtailed (GFR < or = 50 ml/min per 1.73 m2). We conclude that CSCH is valid in predicting GFR only in children with normal renal function and mild insufficiency.

摘要

在患有肾脏疾病的儿童中，研究了施瓦茨公式（CSCH）准确估计肾小球滤过率（GFR）的能力。以125碘-碘肽酸盐清除率（CIO）作为测量GFR的参考标准。将对133名儿童（年龄在1至18岁之间）进行的176项CIO研究数据与通过CSCH同时估计的GFR进行比较。CSCH对GFR的高估与肾功能水平成反比。当CIO>90 ml/min per 1.73 m2时，CSCH对GFR的高估仅为0.1%±3%，但当CIO≤15 ml/min per 1.73 m2时，CSCH对GFR的高估为164%±42%。当肾功能正常或轻度降低（GFR>50 ml/min per 1.73 m2）时，CSCH对CIO的高估仅为10.3±3.0%，而当肾功能中度至重度受损（GFR≤50 ml/min per 1.73 m2）时，这一比例为90.3±14.5%。我们得出结论，CSCH仅在肾功能正常和轻度不全的儿童中预测GFR有效。