Voigt J P, Huston J P, Voits M, Fink H
Institute of Pharmacology and Toxicology, Charité, Medical Faculty of the Humboldt University, Berlin, Germany.
Peptides. 1996;17(8):1313-5. doi: 10.1016/s0196-9781(96)00230-6.
The effects of CCK on food intake were investigated under fixed feeding conditions in comparison to a test meal taken after 16 h of food deprivation. The experiments were performed on young adult rats (8 weeks old) as well on aged rats (23 months old). Intraperitoneal CCK-8 (8 and 40 micrograms/kg) significantly reduced the size of a test meal following 16-h food deprivation. This effect was independent of the age of the rats. However, under fixed feeding conditions neither of the doses used in this study reduced food intake in the young adult rats, whereas the highest dose of 40 micrograms/kg did so in the aged rats. These results suggest that the hypophagic effect of exogenous CCK-8 depends on experimental conditions, food intake being reduced after a period of food deprivation but not under a fixed feeding regimen in adult animals. Furthermore, the data suggest that age is a factor contributing to the complex behavioral actions of CCK, because only old animals were more susceptible to an anorectic action of CCK under the fixed feeding schedule. An explanation may lie in an interaction of other known behavioral effects of CCK (e.g., anxiogenic, mnemonic action) with its effects under the different feeding schedules.
在固定喂食条件下，与禁食16小时后进食的测试餐相比，研究了胆囊收缩素（CCK）对食物摄入量的影响。实验在年轻成年大鼠（8周龄）和老年大鼠（23月龄）身上进行。腹腔注射CCK - 8（8微克/千克和40微克/千克）可显著减少禁食16小时后测试餐的量。这种作用与大鼠的年龄无关。然而，在固定喂食条件下，本研究中使用的两种剂量均未减少年轻成年大鼠的食物摄入量，而最高剂量40微克/千克却减少了老年大鼠的食物摄入量。这些结果表明，外源性CCK - 8的促食欲作用取决于实验条件，在成年动物中，禁食一段时间后食物摄入量会减少，但在固定喂食方案下则不会。此外，数据表明年龄是影响CCK复杂行为作用的一个因素，因为只有老年动物在固定喂食时间表下对CCK的厌食作用更敏感。一种解释可能在于CCK的其他已知行为作用（如致焦虑、记忆作用）与其在不同喂食时间表下的作用之间的相互作用。
