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Dissociate arachidonic acid release from eicosanoid synthesis in rat peritoneal macrophages is possible using concomitantly eicosapentanoic acid as a phospholipid analogue.

作者信息

Bourass J, Boucrot P, Letourneux Y, Gandemer G, Petit J Y

机构信息

Laboratoire de Synthèse et d'étude des Substances Naturelles à Activité Biologique, Põle Sciences, La Rochelle, France.

出版信息

Pharmacol Res. 1996 Jun;33(6):343-7. doi: 10.1006/phrs.1996.0047.

DOI:10.1006/phrs.1996.0047
PMID:8971956
Abstract

Activated macrophages exposed to the association of eicosapentanoic acid 20:5 n-3 and a synthetic non hydrolysable phospholipid analogue maintained a discrete synthesis of active eicosanoids. 20:4 n-6 split from the internalized 20:4-GPC was accumulated in cells and extracellular fluids. This combination thus represents a novel approach to reduce the 20:4 n-6 cascade.

摘要

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