三种嗜角质真菌对某些维可霉素敏感性的实验室评估

Laboratory evaluation of sensitivity of three keratinophilic fungi to some vicolides.

作者信息

Rai M K, Vasanth S

机构信息

Department of Botany, Danielson College, Chhindwara, India.

出版信息

Hindustan Antibiot Bull. 1995 Feb-Nov;37(1-4):48-50.

PMID:8972141

Abstract

Four vicolides (sesquiterpenoides) isolated from Vicoa indica were evaluated against three keratinophilic fungi, viz., Microsporum gypseum, Chrysosporium tropicum, and Trichophyton terrestris. All the test fungi were found to be sensitive to vicolides. Vicolides A and C showed the maximum efficacy while B and D exhibited moderate activity. The Minimum Inhibitory Concentration (MIC) was observed in the range of 15.62-125 micrograms. The most sensitive fungus tested was C. tropicum followed by T. terrestris and M. gypseum.

摘要

从印度维柯菊（Vicoa indica）中分离出的四种维柯内酯（倍半萜类化合物）针对三种嗜角质真菌进行了评估，即石膏样小孢子菌（Microsporum gypseum）、热带金孢子菌（Chrysosporium tropicum）和土生毛癣菌（Trichophyton terrestris）。发现所有受试真菌对维柯内酯敏感。维柯内酯A和C显示出最大功效，而B和D表现出中等活性。最低抑菌浓度（MIC）在15.62 - 125微克范围内。受试的最敏感真菌是热带金孢子菌，其次是土生毛癣菌和石膏样小孢子菌。