Manku M S, Horrobin D F, Ally A I, Karmali R A, Karmazyn M, Morgan R O
Prostaglandins. 1977 Aug;14(2):273-7. doi: 10.1016/0090-6980(77)90172-1.
Propranolol is a local anaesthetic, membrane-stabilizing drug as well as a beta blocker. 2 mug/ml is added to many PG bioassay systems in order to inhibit beta adrenergic effects. This concentration inhibited responses of the rat stomach strip to PGE2 concentrations below 5 x 10(-7)M but potentiated responses to higher PGE2 concentrations. In calcium-free buffer only the potentiation was seen. Propranolol may not be a suitable drug for use in PG bioassay systems.
普萘洛尔是一种局部麻醉药、膜稳定剂以及β受体阻滞剂。在许多前列腺素生物测定系统中添加2微克/毫升以抑制β肾上腺素能效应。该浓度抑制了大鼠胃条对低于5×10⁻⁷M的前列腺素E2浓度的反应，但增强了对更高前列腺素E2浓度的反应。在无钙缓冲液中仅观察到增强作用。普萘洛尔可能不是适用于前列腺素生物测定系统的药物。
