晚期癌症发热和不发热患者脑脊液中前列腺素F2α水平的测定

Measurement of prostaglandin F2alpha levels in cerebrospinal fluid of febrile and afebrile patients with advanced cancer.

作者信息

Landaw I S, Young C W

出版信息

Prostaglandins. 1977 Aug;14(2):343-53. doi: 10.1016/0090-6980(77)90179-4.

Abstract

Prostaglandin F2alpha levels were measured by radioimmunoassay in 95 samples of unextracted human cerebrospinal fluid obtained from 73 patients with advanced cancer. Concentrations of PGE were too low to be reliably determined by this method using the commercially available kits. Forty-six of the samples assayed contained less than 25pg/ml PGF2alpha. The remaining levels ranged from 25 to 1154 pg/ml c.s.f.; the majority contained less than 200pg/ml. A possible correlation was found between elevated c.s.f. granulocyte count and increased PGF2alpha. A similar relationship was found with regard to protein. These studies failed to demonstrate a correlation between elevated levels of PGF2alpha in cerebrospinal fluid and any pathophysiologic condition.

摘要

采用放射免疫分析法对从73例晚期癌症患者获取的95份未提取的人脑脊液样本中的前列腺素F2α水平进行了测量。使用市售试剂盒，通过该方法测定的PGE浓度过低，无法可靠测定。所检测的样本中有46份所含的PGF2α低于25pg/ml。其余样本的脑脊液水平在25至1154pg/ml之间；大多数样本所含的PGF2α低于200pg/ml。发现脑脊液粒细胞计数升高与PGF2α增加之间可能存在相关性。在蛋白质方面也发现了类似的关系。这些研究未能证明脑脊液中PGF2α水平升高与任何病理生理状况之间存在相关性。