Pratt M F, Williams P B
Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, USA.
J Otolaryngol. 1996 Dec;25(6):393-8.
Pentoxifylline has been used experimentally, and acetylsalicylic acid (ASA) has been used clinically to improve skin-flap survival. This study tested the efficacy of each drug in the pig random skin-flap model.
Six flaps were elevated on each hypopigmented pig. After sacrifice on the seventh postoperative day, percent flap survival was determined. Control data were obtained from eleven pigs. Six experimental subjects were treated with pentoxifylline (25 mg/kg/d); six with ASA (8 mg/kg/d); and twelve with a combination of pentoxifylline and ASA (six for 7 days and six for 14 days).
The mean flap survival +/- SEM was: 58.0 +/- 4.3% for the pentoxifylline group; 50.3 +/- 3.4% for the ASA group; 56.8 +/- 2.7% and 55.2 +/- 3.4% for the 7-day and 14-day combination groups, respectively. There was no significant increase in flap survival with any of the experimental groups when compared to controls (49.6 +/- 1.8%).
Red blood cell flexibility and platelet aggregation studies documented the expected intravascular drug effects, but did not correlate well with flap survival.
己酮可可碱已用于实验，而乙酰水杨酸（ASA）已用于临床以提高皮瓣存活率。本研究在猪随机皮瓣模型中测试了每种药物的疗效。
在每只色素减退的猪身上掀起6个皮瓣。术后第7天处死动物后，测定皮瓣存活百分比。对照数据来自11只猪。6只实验对象用己酮可可碱（25毫克/千克/天）治疗；6只用ASA（8毫克/千克/天）治疗；12只用己酮可可碱和ASA联合治疗（6只治疗7天，6只治疗14天）。
己酮可可碱组皮瓣平均存活+/-标准误为：58.0+/-4.3%；ASA组为50.3+/-3.4%；7天和14天联合治疗组分别为56.8+/-2.7%和55.2+/-3.4%。与对照组（49.6+/-1.8%）相比，任何实验组的皮瓣存活率均未显著提高。
红细胞柔韧性和血小板聚集研究记录了预期的血管内药物作用，但与皮瓣存活率相关性不佳。
