Cilla G, García-Bengoechea M, Perez-Trallero E, Montalvo I, Vicente D, Arenas J I
Microbiology Service and Infectious Epidemiology Unit, Hospital Nuestra Señora de Aránzazu, San Sebastián, Spain.
Epidemiol Infect. 1996 Dec;117(3):533-6. doi: 10.1017/s0950268800059227.
The genotype of HCV was determined in 161 chronic HCV-infected patients. The patients were classified into three groups on the basis of the origin of the HCV infection: 50 patients had a history of intravenous drug use (IVDU) but no HIV infection; 41 patients had received blood transfusions, and 70 patients had no known exposure. The distribution of HCV genotypes was associated with the origin of infection and age of patients: genotype 1b was predominant among patients who had received blood transfusions and those without evidence of parenteral exposure (84.6% and 67.7%, respectively), whereas genotype 3a was present in 65.3% of IVDUs. Patients with genotype 1b were older than those with genotypes 1a or 3a: 50.3 +/- 12 vs. 34.1 +/- 9.9 and 31 +/- 5.4 years, respectively. These findings suggest that the pattern of HCV genotypes in our region is changing and that genotype 1b may be substituted by 3a as the dominant genotype in the future.
对161例慢性丙型肝炎病毒（HCV）感染患者进行了HCV基因型测定。根据HCV感染源将患者分为三组：50例有静脉吸毒史（IVDU）但未感染HIV；41例接受过输血，70例无已知暴露史。HCV基因型分布与感染源及患者年龄相关：1b型在接受过输血的患者和无肠道外暴露证据的患者中占主导（分别为84.6%和67.7%），而3a型在65.3%的静脉吸毒者中出现。1b型患者比1a型或3a型患者年龄大：分别为50.3±12岁、34.1±9.9岁和31±5.4岁。这些发现表明，我们地区HCV基因型模式正在发生变化，未来1b型可能会被3a型取代成为主导基因型。
