Camilleri-Bröet S, Molina T, Audouin J, Tourneau A L, Diebold J
Department of Pathology, Hôtel Dieu, Paris, France.
Virchows Arch. 1996 Nov;429(4-5):243-8. doi: 10.1007/BF00198340.
T-cell-rich B-cell lymphoma (TCRBCL) is an unusual lymphoma which is difficult to diagnose. A majority of reactive T-cells and numerous histiocytes mask the few large neoplastic B-cells. Fourteen cases of TCRBCL were studied in order to identify the main histological and cytological features useful for this diagnosis. Neoplastic cells are atypical and sometimes difficult to classify. Several types are seen; they are mostly centroblasts, which represent more than 50% of the tumour cells but are sometimes multilobated, immunoblasts- or Reed-Sternberg-like cells. Interestingly, at least two, and often three, types of tumour cell are present in all the cases. Epithelioid cells and histiocytes are always found and are often numerous. Hypervascularization and fibrosis are present in the majority of cases, but without annular bands. Necrosis is absent. All tumour cells express CD20 but EMA is expressed in less than half the cases. In two cases, the association of a diffuse large B-cell lymphoma in one site and a TCRBCL in another suggests that TCRBCL may be considered as a peculiar pattern of a diffuse large B-cell lymphoma with a strong stroma reaction. TCRBCL may not represent a clinicopathological entity.
富含T细胞的B细胞淋巴瘤（TCRBCL）是一种难以诊断的罕见淋巴瘤。大多数反应性T细胞和大量组织细胞掩盖了少数大的肿瘤性B细胞。对14例TCRBCL进行了研究，以确定有助于该诊断的主要组织学和细胞学特征。肿瘤细胞不典型，有时难以分类。可见几种类型；它们大多是中心母细胞，占肿瘤细胞的50%以上，但有时呈多叶状，还有免疫母细胞或里德-斯腾伯格样细胞。有趣的是，所有病例中至少存在两种，且通常为三种类型的肿瘤细胞。上皮样细胞和组织细胞总是存在且通常数量众多。大多数病例存在血管增生和纤维化，但无环状带。无坏死。所有肿瘤细胞均表达CD20，但不到一半的病例表达EMA。在两例病例中，一个部位为弥漫性大B细胞淋巴瘤，另一个部位为TCRBCL，这表明TCRBCL可能被视为一种具有强烈间质反应的弥漫性大B细胞淋巴瘤的特殊类型。TCRBCL可能并不代表一种临床病理实体。
